Can donating organs be painful even after you’ve flatlined?

Scientists have broadened the definition of death, but it’s extremely unlikely that donors suffer

Sean Kirkpatrick/Flickr

Sometimes, there’s no better place for science-ish speculation than at the dinner table. Last weekend, my mother was offended that she didn’t know her children and husband had signed up to donate their organs. My father, a man of reason, couldn’t see why one would get emotional about the issue: “What does it matter once we we’re dead?” That’s when my dear aunt piped up: she insisted she’d heard somewhere it’s possible to feel pain while the organs are extracted in that final act of altruism.

The claim seemed absurd at first. But Science-ish learned that she was actually speaking to a wider controversy about organ donation and the complex question of when a person is dead. In fact, as Dick Teresi, author of the forthcoming book The Undead, told Maclean’s in an interview for this week’s issue: “It’s easier to be declared dead than ever before.” He also added: “(Deceased donors’) brain stems aren’t working, but vital organs still function—you’ll pee, maintain your body temperature, and your wounds will continue to heal. You may—it’s not certain, but you might—feel pain during surgery. You’re in this weird undead zone. It’s during that time your organs are taken.”

So if your organs are working, are you dead?

Science-ish called Dr. Andreas Kramer of the Hotchkiss Brain Institute at the University of Calgary to find out. He explained that organ donation used to be performed in Canada only in “neurologically devastated” individuals who fit the criteria of “brain death” that Teresi referred to in conversation with Maclean’s. Brain death was a concept established at Harvard in 1968, when a committee of researchers determined that a person could be declared dead legally if, among other things, blood flow to the brain stopped even though other organs continued to work. Needless to say, people who suffer brain deaths are perfect candidates for organ donation.

As Dr. Kramer explained: “(With brain death) there is no evidence of brain activity, even very basic physiological functions, such as respiration. The only reason that the heart continues to beat is because they are on life support at the time that they progress to brain death and a ventilator continues to breathe for them.”

More recently, though, another definition of death has cropped up: cardiac death, or the irreversible cessation of circulatory and respiratory function. In other words, when you’re heart stops beating. Today, in Canada, either of these two conditions are sufficient to declare a person dead and treat her as an organ donor.

So an individual—say, the sufferer of a stroke—can meet the criteria for cardiac death, despite the fact that they are not brain dead. In this case, after life support is discontinued and palliative care administered, Dr. Kramer explained, doctors wait to see “if the patient’s heart stops within a predefined period—usually two hours—then they can proceed to organ donation.” After the heart fails, physicians (who are notably not transplant surgeons so there’s no conflict of interest) wait for several minutes before declaring the patient dead.

This is where things become more interesting: that wait period varies across jurisdictions. “In Canada, the U.K., and Australia, almost all hospitals use five minutes,” said Dr. Kramer. “In the U.S, some hospitals use two minutes. In Europe, some hospitals use ten minutes.”

What about the pain?

Given the blurry lines around the final curtain call, can someone who meets the clinical criteria for brain death or cardiac death be aware of pain as their organs are extracted?

In the case of cardiac death, according to Dr. Neil Lazar, an associate professor of medicine at the University of Toronto who has written about deceased organ donation: “if you ask whether a person whose brain has not been receiving blood flow for five minutes is able to experience pain, the answer to that is that it’s very unlikely. The brain is no longer getting blood flow. . . You can ask, ‘What if somebody came along and tried to restart the heart or artificially got blood flowing to the brain–would that brain be able to recover to any extent?’ The answer to that is uncertain.” He emphasized that the patient is almost always so close to the edge that any kind of resurrection would be next to a miracle.

The possibility of feeling pain is extremely remote with brain death as well, for two reasons. Declaring someone clinically brain dead requires, among other things, making sure that the patient does not respond to external stimuli, including pain. “So it’s hard to imagine under those circumstances there would be some unconscious awareness or pain,” said Dr. Lazar.

Could one study pain in dead organ donors? Dr. Kramer said,  “one could theoretically use electroencephalograms (EEG) in donation after cardiac death patients at the time that death is declared—five minutes after cardiac arrest—but this does not definitively tell you whether a patient has any awareness.” Besides, in brain dead patients, the EEG is flat because there is no brain activity, and with cardiac death, the EEG usually flattens in less than five minutes. So while we don’t have evidence to prove an organ donor can’t feel pain, we also don’t have evidence to indicate that they could, and the latter is extremely unlikely.

All of this makes Science-ish wonder about the big question: how do you really know when a person is dead? Is it about the cessation of brain function? A heart beating its last? “If people say you have to be dead to be an organ donor, there will always be individuals who will say, ‘I don’t agree with that diagnosis of death. The heart is still beating, so how do you call that person dead?’ ” said Dr. Lazar, “death is a social construct. It just so happens that doctors are the professionals who have been given the authority declare it.”

Science-ish is a joint project of Maclean’s, The Medical Post, and the McMaster Health Forum. Julia Belluz is the associate editor at The Medical Post. Got a tip? Seen something that’s Science-ish? Message her at julia.belluz@medicalpost.rogers.com or on Twitter @juliaoftoronto




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Can donating organs be painful even after you’ve flatlined?

  1. For goodness’ sake, if it is a question of a single instant of pain to save another’s life, I am confident any Canadian– and hopefully any human– would be more than willing to endure. This bold headline and focus on “feeling pain” is an attention grabbing disgrace for a magazine such as Maclean’s.

    • Yes, I was looking for the followup on how important organ donation is and how tissue can be donated even from older donors.  Also, my guess is that people aren’t as concerned about “pain” as that they might be “hurried into a state of death” so they can get the organs, which is of course not true.

      • you are right, it is not true. they did not even concider organ donation until my daughter started having stokes to her brain and showed signs of cardiac arrest.

  2. As the sign so aptly says, “Don’t take your organs to heaven – God knows that they are needed here”.

  3. The most important thing you can do if you want to be an organ donor is to MAKE SURE YOU TELL YOUR FAMILY…signing a donor card can be overruled by your family.

  4. My daughter suffered many stokes to her brain after a severe accident. After 10 days and many painful strokes to her brain we granted her wish to be an organ donor. She was a nursing student named Brande Nicole Denson. you can google her or me Sherry Sellers and see how the 7 people she saved loves her and our family. I doubt after being tested for brain death and the strokes that she suffered, the removed organs created any pain. Please learn about organ donation. Please understand that without donation, not only do others die, but our doctors have no research or education.

  5. My sister had lifelong depression, due to a severe head injury as a child.  She was on anti-depressants for years. When she finally seemed to be on the right meds, she committed suicide. She wanted to be an organ donor, and after she died they took what they needed. My mother is very religious and is telling me that she has felt someone touch her several times and nobody was there. Can a person rest in peace, if their organs are living in other people who needed them? I know this probably seems weird but who has really thought of it in that way?

    • I have been present at several deaths.  It has taught me that the body (including the organs) is just a shell.  Once the person is unconcious and brain dead, they have left that shell and no longer exist as the person you recognize.  Once that shell stops receiving oxygen, it decays.  Your choice is to let the parts of the shell live on in someone else or die forever and decay.  If you believe in heaven, we know we don’t take our physical body there…we can’t.  The donation of organs is about giving people who have a chance to live the opportunity the dying person cannot take…an opportunity to seize life with the gift of your family member’s organs.  It is a pretty gift that otherwise will go to waste.

  6. a very interesting article, and i sure don’t have the answers, i do know after you chop off a chickens head the heart beats for a while,a bear may get shot in the heart and it can travel for over a mile even though it’s bleeding and frothing blood throught the mouth and nose, don’t ask me when to declare someone/thing is dead

    • I had a health teacher who told me that during the French revolution, they dropped a hot plate on beheaded people at the gullotine and laid bets on how far they would run without their heads….
      The chickens, the bears, the people (if the story is true) undoubtedly were operating on adrenaline.  They run until they bleed out.  Without a brain, you are dead. 

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