An MS trial reported ‘definitive’ results before it was done. Why?

Results from a key Canadian study into venoplasty for MS appear to have been prematurely released, leaving questions

Dr. Daniel Simon points to the dye running through the jugular vein of Neelima Raval, 38, who has lived with multiple sclerosis for 13 years, and who is being tested for narrowed veins by Dr. Simon at the John F. Kennedy Medical Center in Edison, N.J., June, 8, 2010. Dr. Paolo Zamboni, a vascular surgeon from Italy, believes that the disease, which damages the nervous system, may be caused by narrowed veins in the neck and chest that block the drainage of blood from the brain, and has reported in medical journals that opening those veins with the kind of balloons used to treat blocked heart arteries can relieve symptoms. (Beatrice De Gea/The New York Times/ Redux)

Dr. Daniel Simon points to the dye running through the jugular vein of Neelima Raval, 38, who has lived with multiple sclerosis for 13 years, and who is being tested for narrowed veins by Dr. Simon at the John F. Kennedy Medical Center in Edison, N.J., June, 8, 2010. Dr. Paolo Zamboni, a vascular surgeon from Italy, believes that the disease, which damages the nervous system, may be caused by narrowed veins in the neck and chest that block the drainage of blood from the brain, and has reported in medical journals that opening those veins with the kind of balloons used to treat blocked heart arteries can relieve symptoms. (Beatrice De Gea/The New York Times/ Redux)

On March 8, 2017, findings from a Canadian-government-funded clinical trial looking into a treatment for a vascular condition associated with MS were rolled out with carefully orchestrated fanfare. The tone was set by a press release issued by the University of British Columbia and Vancouver Coastal Health Research: “Controversial ‘liberation therapy’ fails to treat multiple sclerosis,” the headline read. The study, the release said, provides “the most definitive debunking of the claim that patients could achieve dramatic health improvements from a one-time medical procedure.” Lindsay Machan, a UBC associate professor of radiology and one of the study’s investigators is quoted: “We were committed to meticulously evaluating this treatment with robust methods and patient-focused outcomes.”

Reading the announcement, one would conclude the tortuous and contentious eight-year quest for research into the benefits of venous angioplasty for people with MS had come to an end. It proclaimed  a “debunking,” a word that bristles with non-scientific ridicule and agenda.  Declaration of “definitive” research also lacked scientific curiosity; science advances by proving science wrong.  Talk of “meticulous evaluation” raised questions as well: lists the UBC-Vancouver Coastal Health-led $5.4-million trial as still “active,” with an “estimated completion date” as September 2017. No one expected to hear from the researchers for months. Yet there they were with 48-week data—a short timeline, as anyone familiar with research into a condition as variable as MS knows. What was going on?

Questions mounted throughout the day. Machan presented “Week 48 results” before the Society of Interventional Radiologists (SIR) annual meeting in Washington, D.C. There was no abstract, no poster, no peer-reviewed study of the sort associated with new scientific research. Instead, 33 slides relayed that 49 subjects had been treated with venoplasty and 55 with a “sham” (the surgical equivalent of placebo). The researchers found no difference in benefits, as reported by the patients or determined by physicians.

Anthony Traboulsee. (Martin Dee/UBC)

Anthony Traboulsee. (Martin Dee/UBC)

North of the border, the clinical trial’s director, Anthony Traboulsee, went on a one-day media blitz. Traboulsee, an MS neurologist and director of the MS Clinic at the Djavad Mowafaghian Centre for Brain Health at UBC, has produced other research  “debunking”  a theory put forward by Italian venous specialist Paolo Zamboni who hypothesized blocked veins impeding blood flow was common in people with MS;  he classified these patterns as “cerebrospinal venous insufficiency,” or CCSVI. Zamboni’s small 65-person observational study concluded venous angioplasty improved or even eliminated MS symptoms; it called for further randomized controlled clinical trials. CCSVI has been the subject of international research producing conflicting results ever since.

Now, here was Traboulsee saying that CCSVI has been conclusively studied; it was time to move on. “I don’t see any benefits to people pursuing this treatment after the results of our study,” he told the CBC last week. The file on CCSVI should be closed, he told CTV News: “It’s done.”

The gleeful “debunked” message was echoed in media. The CBC ran with: “‘Scientific quackery’: UBC study says it’s debunked controversial MS procedure.” Multiple Sclerosis News Today proclaimed “So-Called ‘Liberation Therapy’ for MS is Useless, Costly and Potentially Dangerous, Study Finds,” though the findings suggested no risk and did not mention costs.

Husband and wife Geoff and Caroline McNeill both suffer from multiple sclerosis.

Husband and wife Geoff and Caroline McNeill have both been diagnosed with multiple sclerosis.

The announcement of “definitive” trial results surprised no one more than Geoff McNeill, one of the trial’s 104 participants. The 47-year-old, who lives in Langley, B.C., was blindsided by the newspaper stories, he told Maclean’s. He has a follow-up assessment scheduled for May, a seven-hour battery of tests and an MRI. “I am one of the 104,” he says. “Why isn’t my experience included?”

He’d committed more than 30 hours to the trial, not counting the 90-minute drive back and forth from his house to UBC. He reports a positive and marked difference between two interventions. Yet, in a trial focused on “patient-focused outcomes,” his experience after his second procedure had not been studied.

McNeill, a chartered shipbroker, joined the trial in 2015 inspired by his wife, Caroline, who was diagnosed with MS in 2006. She was one of the tens of thousands of Canadians who travelled out of the country, against the advice of MS neurologists, when the treatment was not made available in Canada (venoplasty is covered for other conditions under provincial health plans).

The exodus put a spotlight on a patient population eager for new approaches—and frustrated with the MS status quo. More than 100,000 Canadians and 2.5 million worldwide have been diagnosed with MS, a condition that has confounded medicine for a century and a half. It often strikes young, between 15 and 40, and is three times more common in women. MS is unpredictable; over time, it can render people blind and paralyzed, or it may not. There is no known cause, cure or definitive test.

Anecdotal reports of CCSVI treatment varied. (It was dubbed “liberation therapy” by staff at Zamboni’s hospital in Italy and later the media.) Quickly it was evident it was not a “cure.” Some saw significant improvements, while others experienced improvements that dwindled; others felt no change. Adverse effects post-treatment were reported, some of them dire. Two Canadians died with post-operative complications, one man after being denied aftercare in Canada.

Caroline McNeill’s experience, though, was positive: a surge in energy, which abated in time. She returned to New York state for a second treatment; the results were not as pronounced. She travelled again, to California, where a blockage was cleared and she felt marked improvements. Then, in 2011, Geoff was diagnosed with MS. He considered traveling for CCSVI treatment but couldn’t afford it at the time. But he was excited when he was accepted in 2015 for the Canadian clinical trial.

McNeill says he was surprised when he learned Traboulsee, his neurologist, was leading the the study, given how dismissive he had been of CCSVI both publicly and personally.  Still, he was hopeful, not only because the treatment might offer symptom relief, but also because he wanted to contribute to the science.  In June 2015, he underwent the first intervention, not knowing whether it was venoplasty or a sham, per the trial’s “blinding.” He felt no different. In May 2016, he had “crossover” treatment (those who’d received “sham” underwent venoplasty and vice versa). After that, he could run up the stairs for the first time in years. He was able to return to the slopes with his two children. Over the next months, some benefits abated (he says he can no longer could run up stairs, but he skis).

Maclean’s interviewed Traboulsee last week during his media rounds. After hearing McNeill’s story after that interview, Maclean’s contacted UBC to share McNeill’s concern and to ask about the status of its data collection. The “clinical trial and patient evaluation is continuing,” a UBC spokesman, speaking on behalf of Traboulsee and Maclan, said in an email. He said that patients had been informed 48-week results would be released (McNeill says he hadn’t been told). Not all data was in, the UBC spokesman said: “post-crossover data of all participants are still being collected and they are continuing to be monitored….Those results will be included in the final data set.” Maclean’s second query asking why results had been announced as “definitive” when data analysis was incomplete, sent to both UBC and Traboulsee, remains unanswered. (This post will be updated if and when it is.)

Release of clinical trial results before the database is officially closed is unusual, one expert in clinical trial design told Maclean’s. Unable to review the UBC trial protocol, he asked his name not be used. Maclean’s request for the protocol from Canadian Institutes of Health Research, the primary funder—the MS Society of Canada, and the provinces of British Columbia, Manitoba and Quebec also provided funding—was redirected to UBC, who did not supply it.

Data is released early under a few circumstances, the expert says: “One, the results of an ‘unblinded’ futility analysis concludes that with the data available there is no significant effect; and, two, the Medical Safety Review Board concludes the incidence of adverse and serious adverse events outweigh the possible benefits. If there was an independent ‘unblinded’ board which was reviewing data real time and the statistician concluded ‘futility,’ then the trial could be stopped—but that does not appear to be what happened in this trial.”

Why UBC released the data early is unclear. Doing so succeeds in getting their preliminary data out before two other CCSVI clinical trials report. One, in Australia, is ongoing. The second, a 360-person Italian trial which commenced in 2012 is expected to report in mid-2017, after it is peer-viewed and published,  Zamboni reported in November. UBC researchers submitted their presentation to the SIR meeting after that announcement, and the meeting’s Sept. 30 submission deadline. It’s not unprecedented to share early results, Traboulsee told Maclean’s. “We debated that. We had an obligation to get the results out in a timely manner.”

The SIR meeting was chosen because interventional radiologists (IRs) are interested in the procedure, Traboulsee says. Yet that presentation didn’t focus on measurements used by interventional radiology—blood flow, venous pressure, size of stenosis, restenosis rates. That concerned Salvatore Sclafani, a Brooklyn, NY-based IR who attended the meeting. Without such before-after data, it’s impossible to know whether the trial properly treated CCSVI, he told Maclean’s.

CCSVI treatment has evolved markedly since 2009, says Sclafani, who has performed hundreds of procedures. Nothing he saw at the meeting would cause him to change his protocol or willingness to treat, he said. “The study was focused on proving Zamboni’s early study right or wrong,” he says. “We need to see the paper.”

(BSIP/UIG/Getty Images)

(BSIP/UIG/Getty Images)

The declaration that CCSVI research is “done” leaves unanswered why many people with MS reported symptom improvements that have been lasting, some quantifiable. One high-profile example is Jeff Beal, North America’s CCSVI Patient Zero who talked about his experience at the Sundance Film Festival last month. The Los-Angeles-based composer known for his work in film, TV and symphony, was treated at Stanford Medical Centre in 2009; he had returned for retreatment. Beal’s energy, cognition and sleep patterns improved markedly after, accompanied by a new diet and exercise regimen. Some improvements were measurable: reversal of gray matter atrophy on MRI, a doubling of jugular vein blood volume, no new MS lesions, and shrinkage of older ones.

Burnaby, B.C. resident Lori Batchelor also experienced enduring improvements; she provided Maclean’s with medical records from her UBC neurologist, John Hooge, now retired. Batchelor had secondary progressive MS when she traveled to the US in March 2011. Her EDSS (a 0-to-10 MS disability scale in which 10 is “death due to MS”) rose from 2 in 1993 to 6.5 in 1998; in 2013, after treatment, it improved to 4, where it has remained. A March 8, 2012 note from Hooge to Batchelor’s GP read in part: “Lori is better than she was a year ago. She is walking better and her right leg is stronger. This appears to have occurred following the procedure for CCSVI.”

Senator Jane Cordy, who introduced a Senate bill in 2011 calling for accelerated research into CCSVI, was inspired to do so after hearing dozens of stories firsthand, she says. “One woman went from bedridden to presenting at a CCSVI meeting on the Hill,” she says. Another left nursing-home care and was self-reliant.  “Nobody sees the treatment as a miracle cure,” says Cordy. “But people with MS need options.”

Currently those options focus only on MS drugs, a $21.5-billion industry based on the theory MS is triggered by the immune system attacking itself. They’re sold with the promise of reducing relapses and delaying disease progression. Many come with brutal side effects, including death risk. No drugs have yet been developed for those with progressive forms of MS.

Traboulsee highlighted the benefits of MS medications in last week’s press release announcing the “debunking” of CCSVI:  “Fortunately, there are a range of drug treatments for MS that have been proven, through rigorous studies, to be safe and effective at slowing the disease progression,” he is quoted saying. Like many MS neurologists, Traboulsee works actively with industry in new drug development. (Recently he has been a spokesman for the MS drug Lemtrada and also is running a tranche of an international clinical trial for the Genentech/Roche drug ocrelizumab (Ocrevus) which he has praised publicly.)

Such relationships don’t represent financial conflicts of interest or compromise his objectivity, Traboulsee told Maclean’s last week. The trial’s design had “layers of protections built in to avoid bias,” he says, including an independent data monitoring board, independent trial monitors, and a data-locking process before data was sent to statistician. “We weren’t out to beat [CCSVI] up.”

When the limitations of MS drugs was pointed out to him by Maclean’s, Traboulsee agreed, in part. “Unfortunately those drugs are not reversing the disability and improving symptoms,” he says. “What the ‘liberation therapy’ has brought to light is that is the need.”

Reports of improvement after CCSVI treatment are a conundrum, says Traboulsee: “We all struggle to understand the full reason people get better.” It could stem from the variability of the condition or “placebo effect,” he suggests. His group looked at who might benefit, with no luck. “We tried to look at all the baseline features—if you had relapsing remitting MS, if you were a woman, a certain age, if you had enhancing lesions on your MRI—could any of these factors predict a better outcome?” Asked if it should be an area of further research, he prevaricates: “The fact that people get better, I’d love to know why they get better so we can tap into that and help more people get better.”

The proclamation CCSVI “is done” ignores a new vanguard of research outside of MS neurology committed to investigating the link between neuro-degenerative diseases, blood flow, and the vascular system.  The discovery of a brain lymphatic system in 2015, for example, stands to revolutionize understanding of the brain, and hopefully provide new insights into diseases like MS, Alzheimer’s and Parkinson’s.

CCSVI, enshrined medically in a chapter in the 2016 edition of the Oxford Textbook of Vascular Surgery, is also being associated with other disorders. A study presented at the SIR meeting found high incidence (89 percent) of CCSVI in people diagnosed with Meniere’s disease, an incurable degenerative inner ear disorder whose symptoms include intense nausea and dizziness, vertigo and tinnitus. Like MS, its aetiology is unknown and has been linked to viral infection and autoimmune reaction. Venous angioplasty, the study found, reduced Meniere’s symptom severity.

A few MS neurologists remain curious. Alireza Minagar, who teaches at Louisiana State University, told CTV News he believed further research is needed. CCSVI is in its “infancy,” he said. Like Zamboni, he calls for “collaborative” multidisciplinary research into MS and other neurodegenerative diseases.

McNeill expresses concern the results released last week will have a tamping effect. “Please don’t let this be the end of Canada’s investigation into CCSVI,” he says. Signs of shutdown are evident. The day preliminary clinical trial results were released, the CIHR and MS Society of Canada announced the “working group” created in 2011 to study CCSVI had been wound down the previous day. The same afternoon the  FDA issued a warning on venous angioplasty being used for autonomic disorders, including MS.

“I’m not a militant MS’er for CCSVI,” says McNeill. “But I believe there is something to it. I witnessed it with my wife and I experienced it,” he says, though he does not know which procedure occasioned his improvement. “Whether it’s a combination of factors or a piece of a puzzle, I don’t know.” He will honour his commitment to complete the trial, he says. “What they do with my data, well, I guess I have to hope for the best.”

Last week, Traboulsee sounded conclusive. “It would have been great if we had something new we could have offered patients,” he told Maclean’s. “And we will have something new to offer patients. I just don’t think this is it.” It’s a telling remark, reflecting the traditional doctors’ perspective of dispensing medicines. Yet it also exists at disconnect from the new reality: a patient population with a devastating disease using social media to share medical experiences and advocate for new avenues of inquiry. The release of “definitive” and “debunking” results from a clinical trial still ongoing is only destined to widen the chasm between the two.


An MS trial reported ‘definitive’ results before it was done. Why?

  1. Thank you to Anne Kingston from me here in the UK I have fought MS for 45 years NO MS meds ever to prove medics wrong about MS. Everyone deserves CCSVI the new way forward for us all with MS Worldwide.

  2. Thank you for going beyond the biased UBC media release! I do not believe the Pan-Canadian trial was done in good faith. Rather than real investigation on the effect of correcting impaired blood flow on some symptoms attributed to MS, I believe the design was to make it “appear” that treating CCSVI would not have any effect on MS symptoms. Nobody expects this to be a cure but it may improve quality of life for some!

  3. Having talked to Lindsay Machan at the conference, Salvatore Sclafani (in an interview) noted that the Traboulsee trial used small and low pressure venoplasty balloons. In contrast, the surgeons treating people with MS use large and high pressure venoplasty balloons. So the Traboulsee team has “debunked” a venoplasty procedure that isn’t used outside his own “clinical trial”! Having seen my wife have a miraculous experience with venoplasty in California, (many benefits still maintained 3 years later) and having seen Traboulsee’s performance in the “ms wars” documentary, I am not surprised. I am however astounded that a guy who exudes bias ever got put in charge of a $6 Million trial! That includes a serious chunk of public money. The real questions are 1. Why they refused to use the right venoplasty balloons and 2. Can these 104 people be rescued by another procedure? (Using the RIGHT balloon size and pressures). In researching the option for my wife, way back in August 2013, even I knew that surgeons had moved to higher pressure venoplasty balloons based on better results. So how could the Traboulsee team be so irresponsible, to use the WRONG balloon sizes and pressures 3 years later? I feel that there should be a new trial. In a federal court.

    • I want more pieces like this one in mainstream Canadian media. Neurologists like Traboulsee are behaving more like politicians and less like scientists. Our family has experienced tangible benefits from CCSVI. We know CCSVI is not a cure. But many of the major MS drugs have great risks – including death. CCSVI does not cause PML. The influence of large pharmaceutical corporations is real and impacts MS research at all levels. Those who deny facts and cease inquiring further do not serve science. They serve a different god.

  4. If the MS drug industry reported as worth $21.5-billion annually is referring only to the Canadian component that translates to $589 per man woman and child per annum. I can see why, from a strictly business perspective, that territory would be fought over.

    The implications of this story are appalling and serve further to undermine my faith in contemporary medicine—not all of it; there looks to be great work done in some sectors such as necessary surgical procedures—but definitely those parts which promise high and on-going profits.


    The Huffington Post has reported a much different story regarding the reporting of the early results. It says the results published in Lancet, indicate that MS patients and the control group had equal numbers of narrowing of veins so that meant people with narrowing of veins didn’t necessarily have symptoms of MS. It said they had yet to evaluate how libation therapy worked for MS in those who had the narrowing of veins and the disease. Anne Kingston, maybe you should have sourced the Lancet.

      • The Traboulsee lancet article is not without its problems. He measured veins in a different way than Zamboni. Zamboni wrote a reply about this to the lancet but they refused to publish it! I think Traboulsee measured an “average” width over a length of vein. This is highly problematical. Chrissy Amphlett of the Australian rock band Divinyls had venoplasty for her MS and made a great recovery. The surgeon commented “you had the largest jugular I have ever seen!” So a blockage at one point (very often a damaged valve) often causes the vein to bulge out above the blockage! Poor Chrissy ended up dying of cancer. I have seen a video of her before the operation and then a year or so after when she resumed singing after the MS hiatus. (She was unable to concentrate before the venoplasty)

  6. I’d almost forgotten what real investigative journalism is. This is a tenaciously researched and informative article. Unfortunately it confirmed all of my cynicism directed towards the ‘science’ industry, but that is exactly what we all need. Scientists are just another group of humans with precious careers, huge mortgages and kids in private school. Objectivity is just a useful illusion.

    • And are journalists any more objective?

  7. If this was submitted as an oral abstract, then it would have been peer reviewed by the SIR meeting. I am not involved in this business at all, but seems like the author REALLY loves CCSVI suggesting a disclosures note would be helpful. That aside, the bar for scientists and physicians to disclose relationships is far higher than that of journalists…when it is the latter who actually control policy.